The principle leans on the method for assessing the arterial function (endothelium state and arterial stiffness) developed by Doctor of Medicine, Professor Parfenov Alexander Sergeevich, based on photoplethysmographic principle of volume pulse wave registration both at rest and during functional tests (reactive hyperemia test, breathing test, pharmacological tests). This approach provides critical clinical data on the arterial bed status and requires no special training of the test operator. Angioscanning with the help of the company's devices designed in collaboration with A.S. Parfenov allows to estimate the following parameters:
- Endothelium state in the microcirculation system
- State of the endothelium in large muscular arteries
- Arterial wall state (stiffness, augmentation index)
- Central arterial pressure
Parfyonov started working on the method for assessing the endothelial cell state when he was the head of the laboratory of new research methods at the Research Institute of Physico-Chemical Medicine of the Russian Ministry of Health (Director: Academician Y.M. Lopukhin). At that time, most attention was devoted to studying specialized endothelial cells—the so-called reticuloendothelial system. In 1996, under the supervision of A.S. Parfyonov, a PhD thesis on the development of a method for evaluating the reticuloendothelial system was performed in the laboratory. In A.S. Parfyonov's 1998 doctoral thesis "Rheology of Atherosclerosis", which was successfully defended, a chapter of research was devoted to the method of assessing the function of the reticuloendothelial system.
During his work in the USA in 2001-2004 at the University of Maryland and Biotechnology Center, A.S. Parfyonov carried out studies to assess the relationship between endothelial and smooth muscle cells of the arterial wall. While staying in the US, Parfyonov published 12 papers dedicated to the development of new diagnostic methods.
The main work on introducing the endothelial function assessment method into clinical practice was started in 2005 in Russia. A patent application (Russian and RST) was filed in 2006. Currently, A.S. Parfyonov holds a Russian patent and continues patenting his invention in the US and European Union.
In 2007, Parfyonov and his prototype of a device for early detection of cardiovascular diseases became the first winner of the television contest "Thought Factory. Ideas for Russia." In 2008, A.S. Parfyonov won the tender for the R&D initiative "Development of a device for early detection of cardiovascular diseases." The "customer" was the Department of Science and Industrial Policy of the Moscow Government; the "user" was the Health Department.